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The Essential Guide to Dynamic Segmentation & Targeting in Pharma

Explore how commercial pharma teams are shifting to dynamic segmentation and targeting—using timely data and AI-driven insights to identify the right HCPs, adapt strategy faster, and make every interaction count.
Author:
ODAIA Team
Published on
October 9, 2025

Guest Authors/ Contributors:

Industry and field leaders who’ve successfully navigated the shift from static to dynamic targeting. Their practical experience and perspectives are woven throughout this guide to provide both strategic and operational insights for commercial pharma leaders.
Frank Fascinato
ODAIA Intelligence
Peter Harbin
ODAIA Intelligence
Sharon Funk
Avadel Pharmaceuticals
Fan Kang
ODAIA Intelligence

Why Pharma Needs to Rethink Targeting

For decades, the playbook for segmentation and targeting has barely changed. Commercial teams ranked healthcare providers by past prescription volume, slotted them into deciles, and handed the top tiers to the field. The year’s call plan and resource allocation were built on that static foundation.

It worked — sort of. It wasn’t predictable, nor easy to repeat, and produced generic, syndicated insights for the entire market that offered minimal competitive advantage. The data was also stale the moment it arrived and had downstream implications across many aspects of commercial execution, from marketing campaigns to reps’ face-to-face interactions with HCPs and digital engagement across sites and portals.

By the time a list made it through analysis, approval, and rollout, real life had moved on. Doctors retired, switched specialties, or shifted their prescribing. Competitors launched new products. Coverage changed. And none of it showed up until the next annual or semiannual refresh.

The industry tends to treat all high-volume physicians the same. Whether they were already prescribing a product, not writing at all, or even recently retired.
- Sharon Funk
This system wasn't broken, it just wasn't learning. In a world where HCP behavior changes weekly, that's a problem. If your data isn't changing weekly, you're already behind.
- Pete Harbin

Real-time data is everywhere, and static targeting isn’t keeping up. It’s not just inefficient, but actively slows down your ability to adapt. That’s where dynamic targeting can rewrite the script, figuratively and literally.

The Problem with Traditional HCP Targeting

The traditional static targeting model is straightforward and hasn’t changed much for a few decades:

  1. Rank physicians by market based on their historic prescription volume (market decile).
  2. Twice a year, tier them into groups (for example, the top 10%, middle 30%, bottom 60%).
  3. Create sales and marketing resource plans based on tier.
  4. Target the HCPs on the list every quarter based on their grouping.

Some add other layers to the data, like product-specific volume, market volumes, or payer mix. But at its core, it’s still backward-looking and volume-driven data. And the problems stack up fast.

Common Pitfalls of Decile-Based Approaches

Lists are outdated before they’re used, because segmentation is performed on a few times a year while targeting happens quarterly. All top-decile HCPs get the same treatment, whether they’re writing your brand or not. 

Reps have little or no flexibility for behavioral nuance, like promotional responsiveness, engagement with digital campaigns, or local competitive shifts. Most importantly, there’s no context explaining why an HCP should be a priority now.

In Sharon’s experience, it’s not uncommon for reps to receive calls lists that include call on doctors who have after they’ve stopped practicing.

I've seen reps calling on a Tier A doctor who had just retired months earlier, while overlooking a Tier C physician whose writing volume for a competing brand had just taken off.
- Sharon Funk

What is Dynamic Targeting?

Dynamic segmentation and targeting is an AI-powered approach to prioritizing HCPs based on multiple real-time data points, not just prescription volume from the last quarter. 

The model: 

  • Runs continuously in the background
  • Prioritizes HCPs based on multiple real-time signals (more on these below)
  • Adjusts quickly to market changes, not just historical trends

At its core, dynamic targeting answers four critical questions that are top of mind for pharma reps every day:

  1. Who matters most right now?
  2. When is the best time to call on them?
  3. How often should I be in contact?
  4. What message is likely to resonate with them?

The signals can be obvious or subtle. There may be a spike in category prescriptions or a visit to your brand’s website. The goal is to catch relevant signals when they happen, not months later.

Data Signals Used in Dynamic Targeting

The system pulls from a wide mix of data: market and product deciles, changes in payer coverage, how prescribing shifts after a rep visit or other promotion, even patterns in reimbursement. 

It also watches for digital cues like visits to your website, clicks on ads, and content downloads, all signals that an HCP is trying to learn more.

Other industries like retail and automotive have mastered this kind of dynamic customer learning. In pharma, we've been too slow to adapt.
- Pete Harbin

Blend these signals together, and you get a dynamic score that predicts a physician's current relevancey to your brand and potential near-term opportunities.

It can tell reps not just who to call on, but when, how often, and what message to lead with.
- Sharon Funk

How Dynamic Targeting Works in Practice

With ODAIA’s platform, dynamic targeting is driven by connected AI engines. One measures potential value. Another picks up signals of current interest or need. A third distills that data into context that a rep can act on. Together, they refresh priorities weekly—or faster—at the individual territory level.

The difference is immediate: National averages are no longer applied to every territory. Priorities can shift with market realities. Every HCP targeting recommendation comes with a clear rationale and guidance on how best to approach them.

For the field, this shortens pre-call planning and sharpens focus. Instead of wading through a static list, reps start the week knowing exactly where to spend their time—and why.

Dynamic targeting allows you to find new physicians who weren't even on your static lists. It gives you a way to get ahead of changes instead of reacting to them months later.
- Frank Fascinato

What Success Looks Like with Dynamic Targeting

Teams that adopt dynamic targeting see gains in both metrics and morale. As Frank, Sharon, and Pete have all seen, the early gains are hard to miss:

  • New opportunities: Teams discover relevant HCPs that static models miss.
  • Smarter, dynamic call frequencies: High-value HCPs get the right number of visits based on how they respond.
  • Better timing: Sales reps schedule visits around prescribing cycles or engagement spikes.
  • Stronger engagements: HCP-level insights guide not just when to call, but what to say — making conversations more relevant and effective.
  • More time selling: Sales teams spend fewer hours analyzing data and more time with HCPs.

For more examples on how dynamic targeting is transforming commercial pharma , browse our customer showcase.

Making the Shift: Steps to Get Started

Switching to dynamic targeting is as much about change management and bringing people along as it is about a tech upgrade. Six key steps make the difference.

1) Prep Your Organization for Change: Start with the “why.” Reps need to clearly understand how dynamic targeting helps them reach the right doctors with the right patients, not just that they’re getting a new list.

You can’t just hand your teams a new list and expect results. They need to know why these targets matter and why this new list is better than what they had before.
- Sharon Funk

2) Build Buy-In Across Teams: Early adopters can make or break the rollout.Include top performers in early pilot projects. They can get teams believing in a new approach better than any slide deck.

As soon as reps saw the system highlight opportunities they would have missed on their own, adoption accelerated.
- Frank Fascinato

3) Focus on Implementation & Adoption: Leaders play a critical role in reinforcing new behaviors. Managers need support, coaching, and tools so they can translate the data into daily action with their teams.

Managers need training too. They help reps understand the data and ensure that they use it the right way.
- Sharon Funk

4) Measuring & Iterating for Success: Success with dynamic targeting requires a new measurement mindset. Old metrics designed for static models don’t capture the speed and fluidity of this approach. Weekly results and real-time dashboards replace the lag of quarterly reporting, ensuring reps act before opportunities close.

Everybody has to believe in the new approach.
- Sharon Funk

5) Create feedback loops: Dynamic targeting isn’t set-and-forget. Regular check-ins with reps and managers reveal what’s resonating in the field and what needs adjustment. Feedback also ensures the system keeps learning, improving accuracy and trust over time.

Keep checking with the reps and managers to see what’s working and what’s not, and then make the adjustments. The more data you feed it, and the more time it runs, the better it gets.
- Sharon Funk

6) Commit fully: Half measures cause confusion. If leadership relies on static reporting while the field is guided by dynamic targeting, teams get mixed signals and adoption stalls. Clear alignment and commitment at every level are essential.

You can’t have one foot in and one foot out. If you’re going to do this, go all in. Otherwise, reps return to what they know.
- Sharon Funk

If exploring more practical examples and insights on AI adoption is of interest, our recent webinar, AI in Action Today showcases proven strategies from industry leaders navigating this shift.

Looking Ahead: Dynamic Targeting as the Foundation for Omnichannel Pharma

Dynamic targeting isn’t a destination. It’s the foundation for a smarter, more flexible, and responsive commercial strategy. Once real-time targeting is in place:

  • Omnichannel orchestration can become truly personal.
  • Brand messaging can be adjusted in days, not months.
  • Every interaction with an HCP, whether digital or in-person, feeds right back into the model.
Once you have that dynamic view of your targets, you can start lining up your other channels to match. That includes digital touchpoints, marketing content, everything. It all works better when it's pointed at the right people, at the right time.
- Frank Fascinato

With dynamic targeting as the foundation, brand and marketing teams can start connecting campaigns to real business results—aligning with field efforts for more personalized, coordinated engagements. Discover how Campaign Intelligence supports omnichannel engagement.

If we get targeting right, everything else becomes more effective. Whether it's omnichannel, brand strategy, or resource allocation.
- Sharon Funk

The Road to Ongoing Agility & Commercial Effectiveness

Static targeting belongs to an era when the market moved slower and the availability of data was sparse. Today, when data is plentiful, it’s agility that wins.

Dynamic targeting puts reps in front of the right HCPs, at the right time, with the right story, and backs every call with evidence instead of instinct. It shrinks the gap between market change and field action from months to days. The teams that make the shift aren’t just keeping up. They’re getting ahead.

For teams interested in taking a practical next step, ODAIA's Opportunity Analysis offers a clear path forward.

It’s a useful process to build internal alignment, evaluate commercial impact, and generate momentum for change—making it easier to see where dynamic targeting can move the needle for your business.

Opportunity Analysis
Find the HCPs over-engaging and the new opportunities you could be acting on.